IFN-gamma/NF-kB Response
Gene co-expression module in Smooth muscle cells
| Category | Inflammation |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Interferon-gamma/NF-kB inducible gene set: GBP1 and GBP2 (IFNg-induced GTPases), TAPBP (antigen presentation), IL32, TYMP, SOD2 (NF-kB target), NAMPT, SAT1, CFLAR, VAMP5, NFIL3 and PMEPA1. This is a bona fide cytokine-response program in colonic smooth muscle/myofibroblasts (inflamed mucosa), and it neighbors the activated myofibroblast module M117 (which contains the IFN-inducible SERPING1/IFI16), supporting in vivo inflammatory activation rather than dissociation stress (no FOS/JUN/HSPs core; HSPA8 is weak/peripheral).
Genes
ATP6V0B, CCDC71L, CFLAR, CHI3L2, EVA1B, GBP1, GBP2, HSPA8, IL32, NAMPT, NFIL3, PMEPA1, PPA1, PPP1R14B, SAT1, SOD2, SOX4, TAPBP, TYMP, VAMP5
Most correlated modules
- Activated Myofibroblast · correlation 0.73
- ER Chaperone/UPR · correlation 0.69
- Atrophy Proteolysis Program · correlation 0.68
- ER Secretory Trafficking · correlation 0.65
- Non-muscle Actomyosin · correlation 0.64
- BMP-ID3 Matricellular · correlation 0.63
- Type I Interferon · correlation 0.62
- XBP1 UPR Response · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.