SP100 — SP100 nuclear antigen

SP100 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SP100's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Antiviral Restriction Anti-viral	FCRL1, GLS, PPM1K, SP140L, STAT3, TGFB1, TSC22D2, WSB1 +1 more	View in SCUBA
CD4⁺ T cells	Interferon response Anti-viral	ACBD5, AQP3, BTN2A1, BTN3A2, BTN3A3, CISH, EIF2AK2, ERAP2 +23 more	View in SCUBA
CD8⁺ T cells	IFN-gamma Response Inflammation	CASP3, GBP5, IFI16, IRF2, OPTN, SP140, TNFSF10, WIPF1	View in SCUBA
Endothelial	Type I Interferon Response Inflammation	ADAR, DDX60, DTX3L, IFIH1, LAP3, OAS2, ODF3B, PARP9 +3 more	View in SCUBA
Enterocytes	Long-gene nuclear transcripts Technical artifact	CCDC68, DOCK9, SMCHD1, UBR2, XKR9, XRN1	View in SCUBA
Gamma-delta T cells	T Cell Maturation T cell maturation	CDK13, CWF19L2, EMB, EZH1, ICE1, IKZF1, JAK1, KLF13 +16 more
Glial cells	Type I/II Interferon Response Inflammation	GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9 +6 more	View in SCUBA
Mucosal-associated invariant T cell	Type I Interferon Inflammation	DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more
Pericytes	Type I Interferon Inflammatory	IFI16, IFI44L, IFI6, MX1, PPIC, RCN1, TNFRSF1A, XAF1	View in SCUBA
Smooth muscle cells	Type I Interferon Inflammation	BST2, GBP4, HLA-F, IFI6, IFIT2, IFITM1, ISG15, LY6E +3 more	View in SCUBA

About the gene

Chromosome	2: 230415942-230545606
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Host-virus interaction, Transcription, Transcription regulation

Function

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.