SREBF2 — Sterol regulatory element binding transcription factor 2
SREBF2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SREBF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cellular biosynthesis Housekeeping | CCDC32, CTSB, HDGF, MEA1, MESD, MFSD6, MRPS11, MTHFD2 +9 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more | |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | AP1G1, CNOT1, INO80D, JARID2, NAA50, NUP98, PLEKHA2, PLEKHM1 +3 more |
About the gene
| Synonyms | bHLHd2, SREBP2 |
|---|---|
| Chromosome | 22: 41833079-41907307 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism, Transcription, Transcription regulation |
Function
Precursor of the transcription factor form (Processed sterol regulatory element- binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis. Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.