SC5D — Sterol-C5-desaturase
SC5D belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SC5D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Hypoxia/metabolic stress Stress | ALG13, ARL4A, C9orf72, HIP1R, PDE4B, SLC2A3, TENT5C, VPS37B +2 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more | View in SCUBA |
| Gamma-delta T cells | S-phase Proliferation Cell cycle | ANKRD9, BCL6, COPS3, DCXR, ERRFI1, GMNN, GOLIM4, MTHFD2 +6 more |
About the gene
| Synonyms | SC5DL |
|---|---|
| Chromosome | 11: 121292681-121313410 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Function
Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7- dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.