SNRNP200 — Small nuclear ribonucleoprotein U5 subunit 200
SNRNP200 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNRNP200's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hippo Pathway Signaling TCR Signaling | ADAR, ARL8B, BAZ2A, CASC3, CCDC85C, CCNK, CDC73, CDK12 +24 more | |
| Macrophages | General Cellular Maintenance Housekeeping | ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin & Splicing DNA/chromatin regulation | ACIN1, ADAR, API5, BAZ2A, CDC73, CDK12, COPA, FUBP1 +11 more |
About the gene
| Synonyms | ASCC3L1, BRR2, HELIC2, KIAA0788, RP33, U5-200KD |
|---|---|
| Chromosome | 2: 96274338-96321271 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase |
| Biological process | mRNA processing, mRNA splicing |
Function
Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.