UBA2 — Ubiquitin like modifier activating enzyme 2
UBA2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UBA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, FBXO34, HAX1, HECTD1, KMT5C, MRPL50 +7 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ARHGDIA, DDX27, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1 +14 more | |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more | View in SCUBA |
| Macrophages | Ubiquitin-Proteasome System Housekeeping | ACTR10, ADSS2, ATXN10, CAND1, CYRIB, DKC1, DPM1, EIF4E +18 more | View in SCUBA |
| Smooth muscle cells | Vascular SMC Identity Contractility | ADIRF, ARPC1A, BCAM, CCDC3, CRIP1, EFHD1, GPRC5C, GPX3 +10 more | View in SCUBA |
About the gene
| Synonyms | FLJ13058, HRIHFB2115, SAE2 |
|---|---|
| Chromosome | 19: 34428352-34471251 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.