POLE3 — DNA polymerase epsilon 3, accessory subunit
POLE3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLE3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing RNA processing & translation | ARHGDIA, DDX27, DDX59, EIF2AK1, EWSR1, FBXL5, GNL1, GTF2F1 +14 more | |
| Innate lymphoid cells | RNA Processing & Proteostasis RNA processing & translation | BZW1, CBX5, CSNK1A1, DDX21, EIF2S1, EIF3J, ENPP1, FNBP1 +11 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
About the gene
| Synonyms | CHARAC17, CHRAC17, CHRAC2, p17, Ybl1 |
|---|---|
| Chromosome | 9: 113407235-113410675 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.