Metallothionein metal response
Gene co-expression module in Enterocytes
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
The module is dominated by metallothioneins (MT1F/G/M/X/H/E, MT2A), indicating a zinc/metal response and oxidative stress. MT1 genes are highly expressed in colonocytes and are reduced in IBD. TMEM176A/B and BLVRB are peripheral members.
Genes
BLVRB, MT1E, MT1F, MT1G, MT1H, MT1M, MT1X, MT2A, TMEM176A, TMEM176B
Most correlated modules
- Surface colonocyte transport · correlation 0.65
- Surface colonocyte differentiation · correlation 0.64
- Translation Elongation · correlation 0.59
- High-abundance housekeeping · correlation 0.58
- Secretory progenitor Notch · correlation 0.57
- SATB2 colonic identity · correlation 0.57
- Mature colonocyte absorptive · correlation 0.54
- Spectrin-actin scaffold · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.