Spectrin-actin scaffold
Gene co-expression module in Enterocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
SORBS2, SNTB1, ADD3, SIPA1L2 and WNK2 are adaptor and spectrin-actin membrane-skeleton genes. SORBS2 is an actin adaptor, ADD3 caps spectrin-actin, and SNTB1 is part of the dystrophin-associated complex. DEPTOR and PRKCB add signaling. Detection is low but coherence is tight, consistent with a membrane-cytoskeleton scaffold program.
Genes
ADD3, DEPTOR, DNAAF9, FYB2, MBOAT2, PRKCB, SETBP1, SIPA1L2, SNTB1, SORBS2, WNK2
Most correlated modules
- Secretory progenitor Notch · correlation 0.91
- Crypt CFTR secretion · correlation 0.89
- Crypt antimicrobial progenitor · correlation 0.88
- Apicobasal polarity · correlation 0.82
- SATB2 colonic identity · correlation 0.81
- Enterocyte identity TFs · correlation 0.73
- Surface colonocyte transport · correlation 0.71
- Cortical actin junctions · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.