Surface colonocyte differentiation
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
KRT20, AGR3, BMP3, CLDN3, DSP, KLF5, TPM1 and PDLIM1 mark differentiating surface/top-crypt colonocytes. KRT20 and BMP3 are surface markers, and KLF5 drives epithelial differentiation. This is a colonocyte maturation program with junctional and cytoskeletal components.
Genes
AGR3, ATP1B1, BMP3, CLDN3, DSP, KLF5, KRT20, NEURL1B, PDLIM1, SAT1, TPM1
Most correlated modules
- Abundant Transcript Baseline · correlation 0.67
- Metallothionein metal response · correlation 0.64
- High-abundance housekeeping · correlation 0.58
- Surface colonocyte transport · correlation 0.53
- SATB2 colonic identity · correlation 0.51
- Long-gene nuclear transcripts · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.