SATB2 colonic identity
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
SATB2 is the defining transcription factor of colonic (as opposed to small-intestinal) epithelial identity. It co-varies here with PRR5L, FOXP2, PRKG1 and PDE3A. PRKG1 and PDE3A form a cGMP/cAMP signaling axis. Expression is high and uniform, so this reads as a distal colonocyte regional-identity program.
Genes
C1orf21, FOXP2, PALS2, PDE3A, PRKG1, PRR5L, RNF152, SATB2
Most correlated modules
- Apicobasal polarity · correlation 0.82
- Spectrin-actin scaffold · correlation 0.81
- Secretory progenitor Notch · correlation 0.78
- Crypt CFTR secretion · correlation 0.75
- Translational repression · correlation 0.74
- Enterocyte identity TFs · correlation 0.74
- Surface colonocyte transport · correlation 0.71
- Long-gene nuclear transcripts · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.