Crypt antimicrobial progenitor
Gene co-expression module in Enterocytes
| Category | Antibacterial |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
LYZ, HES1, CHRM3 and IFITM2 together with EMP2 and SULF2 suggest crypt progenitor and early secretory or Paneth-like metaplastic cells. HES1 marks Notch-active progenitors, and CHRM3 mediates muscarinic signaling in the crypt. LYZ in the colon indicates metaplastic Paneth-like or inflamed crypt cells, and IFITM2 adds an interferon-inducible antimicrobial component.
Genes
CAMK1D, CHRM3, DIAPH2, EMP2, HES1, IFITM2, LYZ, PTPN13, SULF2
Most correlated modules
- Spectrin-actin scaffold · correlation 0.88
- Secretory progenitor Notch · correlation 0.87
- Crypt CFTR secretion · correlation 0.85
- Cortical actin junctions · correlation 0.77
- Surface colonocyte transport · correlation 0.73
- Epithelial polarity cytoskeleton · correlation 0.70
- IFN-gamma immunoproteasome · correlation 0.68
- Redox Detoxification · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.