UGT2A3 — UDP glucuronosyltransferase family 2 member A3
UGT2A3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UGT2A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PGC1A/ERRG metabolic program Lipid metabolism | CYP2C18, CYP4F12, ENSG00000276490, EPHX2, ESRRG, GIPC2, GLUD1, MATN2 +6 more | View in SCUBA |
| Goblet cells | Anti-inflammatory Lipid Signaling Housekeeping | AQP1, CDCA7, FBL, IMPDH2, PRDX5, PTGDR, RARRES2 | View in SCUBA |
About the gene
| Synonyms | FLJ21934 |
|---|---|
| Chromosome | 4: 68928463-68951804 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.