Apicobasal polarity
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
PARD3B, ANK3, NEO1, VAV3, FOXP1 and MCTP2 are long, broadly expressed genes linked to epithelial polarity and lateral-membrane organization. PARD3B sets polarity and ANK3 organizes the lateral membrane. Expression is high and detection wide (88%), and neighboring modules share the same long-gene character. This points to a polarity and junction program, possibly partly driven by nuclear-transcript capture.
Genes
ANK3, BRINP3, CHPT1, FOXP1, MCTP2, NEO1, PARD3B, VAV3
Most correlated modules
- Enterocyte identity TFs · correlation 0.89
- Crypt CFTR secretion · correlation 0.86
- SATB2 colonic identity · correlation 0.82
- Spectrin-actin scaffold · correlation 0.82
- Long-gene nuclear transcripts · correlation 0.69
- Secretory progenitor Notch · correlation 0.67
- Crypt antimicrobial progenitor · correlation 0.63
- Long-gene nuclear transcripts · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.