Cortical actin junctions
Gene co-expression module in Enterocytes
| Category | Cytoskeletal |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 7 genes have a known function matching the annotation |
Why this annotation
PKP4, MYO1B, NEBL, STXBP5 and GOLGB1 point to cortical actin-myosin and junctional scaffolding linked to vesicle trafficking. PKP4 is a p0071 adherens-junction protein, MYO1B links membrane to actin, and NEBL binds actin. STXBP5 regulates exocytosis and GOLGB1 is a Golgi tether. JAK2 is a signaling outlier. This fits a cytoskeleton-junction program in colonocytes.
Genes
GOLGB1, JAK2, MYO1B, NEBL, PKP4, STXBP5, TTC39B
Most correlated modules
- Crypt antimicrobial progenitor · correlation 0.77
- Secretory progenitor Notch · correlation 0.72
- IFN-gamma immunoproteasome · correlation 0.70
- Focal adhesion actin · correlation 0.69
- Epithelial junction adhesion · correlation 0.67
- Surface colonocyte transport · correlation 0.66
- Crypt CFTR secretion · correlation 0.65
- Epithelial polarity cytoskeleton · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.