Focal adhesion actin
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
PTK2 (FAK), LPP, TRIO, PALLD, UTRN, MYO6, CARMIL1 and KIF13A are focal adhesion and actin cytoskeleton regulators. This indicates an adhesion/migration program in enterocytes, with some long-gene contribution (FRYL, BAZ2B).
Genes
BAZ2B, CARMIL1, COP1, FRYL, KIF13A, LPP, MYO6, PALLD, PTK2, SBF2, TRIO, UTRN, ZSWIM6
Most correlated modules
- Long-gene intronic signal · correlation 0.86
- Epithelial NF-kB response · correlation 0.78
- Epithelial polarity cytoskeleton · correlation 0.77
- Apicobasal polarity scaffold · correlation 0.71
- Cortical actin junctions · correlation 0.69
- YAP cytoskeletal remodeling · correlation 0.64
- IFN-gamma immunoproteasome · correlation 0.63
- Transit-amplifying progenitor · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.