IFN-gamma immunoproteasome
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
PSMB8, PSMB9 (immunoproteasome), CTSS (MHC-II antigen processing), CARD16 (inflammasome regulator), DMBT1 and TXNIP mark an IFN-gamma/inflammatory-induced epithelial state typical of colitis enterocytes. ABCC3 and GOLM1 are also inflammation-inducible. ACTR2, IQGAP1 and TPM3 add a cytoskeletal component, likely reflecting co-induced remodeling in activated epithelium. Neighbor M88 (CASP1, NFKBIZ, CCL28) supports an inflammatory epithelial response.
Genes
ABCC3, ACTR2, CARD16, CTSS, DMBT1, GOLM1, IQGAP1, PSMB8, PSMB9, TPM3, TXNIP
Most correlated modules
- Transit-amplifying progenitor · correlation 0.78
- Redox Detoxification · correlation 0.76
- Epithelial NF-kB response · correlation 0.74
- Epithelial junction adhesion · correlation 0.73
- Long-gene intronic signal · correlation 0.72
- Epithelial polarity cytoskeleton · correlation 0.71
- Cortical actin junctions · correlation 0.70
- Crypt antimicrobial progenitor · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.