ER chaperone/UPR
Gene co-expression module in Enterocytes
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
ER chaperones dominate (CALR, PDIA3, PDIA4, HSPA5, HSP90B1), marking an ER folding / unfolded protein response program. This co-occurs with glycolytic genes (PKM, ENO1) and ANXA2/MARCKS. That combination suggests less mature, secretory-active or stressed epithelial cells.
Genes
ANXA2, CALR, EFNB2, ENO1, HSP90B1, HSPA5, MARCKS, ME1, PDIA3, PDIA4, PKM, SLC22A3
Most correlated modules
- Transit-amplifying progenitor · correlation 0.81
- Respiratory Chain OXPHOS · correlation 0.78
- Actin cytoskeleton · correlation 0.78
- Core energy metabolism · correlation 0.72
- Long-gene intronic signal · correlation 0.69
- Mitochondrial Energy Metabolism · correlation 0.68
- IFN-gamma immunoproteasome · correlation 0.66
- Epithelial NF-kB response · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.