Transit-amplifying progenitor
Gene co-expression module in Enterocytes
| Category | Epithelial development |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
This looks like a proliferative/transit-amplifying epithelial progenitor state. CCND2, MSI2 (stem/progenitor RNA-binding protein) and EHF (epithelial differentiation transcription factor) define it. SLC38A1 (amino acid uptake) and the lipogenic genes ELOVL6 and HSD17B12 indicate growth-associated anabolism, and RBM3 is typical of proliferating cells.
Genes
CCND2, CLINT1, EHF, ELOVL6, HSD17B12, MSI2, PKP2, RBM3, SLC38A1
Most correlated modules
- Long-gene intronic signal · correlation 0.88
- Epithelial polarity cytoskeleton · correlation 0.84
- ER chaperone/UPR · correlation 0.81
- IFN-gamma immunoproteasome · correlation 0.78
- Redox Detoxification · correlation 0.78
- Crypt CFTR secretion · correlation 0.73
- Nucleolar RNA-binding · correlation 0.70
- Respiratory Chain OXPHOS · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.