RNF152 — Ring finger protein 152
RNF152 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF152's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenesis ECM remodeling | ADM, APOD, CHST15, CMTM3, GPIHBP1, GRAP, HOMER3, LOX +7 more | View in SCUBA |
| Enterocytes | SATB2 colonic identity Epithelial development | C1orf21, FOXP2, PALS2, PDE3A, PRKG1, PRR5L, SATB2 | View in SCUBA |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, ATP10A, BBX, CDK18, CSRP2, EDNRA, GPAT2, NR3C1 +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ39176 |
|---|---|
| Chromosome | 18: 61808067-61894247 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Apoptosis, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.