Surface colonocyte lipid-droplet
Gene co-expression module in Enterocytes
| Category | Lipid metabolism |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
ALPI, MUC17 and TMEM37 mark mature apical/top-crypt colonocytes. CIDEC, CIDEB, PLIN3 and LPGAT1 are lipid droplet/lipid handling genes. CDKN1A and SGK1 indicate terminal differentiation and cell cycle exit. IL32 and SERPINA1 are surface-epithelium inflammatory-responsive genes. Overall this reads as a terminally differentiated surface colonocyte program with lipid droplet storage, approaching extrusion.
Genes
ALPI, CDKN1A, CIDEB, CIDEC, IL32, LMO7, LPGAT1, MPP1, MUC17, PLIN3, SERPINA1, SGK1, TMEM37
Most correlated modules
- Amino acid absorption · correlation 0.92
- Brush-border enterocyte · correlation 0.90
- Epithelial junction polarity · correlation 0.89
- Enterocyte fatty-acid catabolism · correlation 0.89
- ER-autophagy homeostasis · correlation 0.88
- TNF receptor signaling · correlation 0.88
- Endocytic nutrient uptake · correlation 0.87
- Stress-responsive transcription · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.