Stress-responsive transcription
Gene co-expression module in Enterocytes
| Category | Stress |
|---|---|
| Genes | 7 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
Mixed gene set dominated by long, stress-responsive transcripts. LPIN2, SKIL (TGF-beta feedback), ABTB2 and TMCC3 are induced by growth-factor and stress signaling. PLEC and AAK1 are long cytoskeletal and trafficking genes. RIGI is an innate sensor. No single coherent pathway is evident. The neighborhood (JUN/FOXO3 in M27, CCNL1 in M91) suggests a mild stress or immediate-response state, possibly dissociation-related. Low confidence.
Genes
AAK1, ABTB2, LPIN2, PLEC, RIGI, SKIL, TMCC3
Most correlated modules
- TNF receptor signaling · correlation 0.90
- Inflammatory hypoxic response · correlation 0.87
- Junctional Hippo/TGF-beta signaling · correlation 0.87
- Surface colonocyte lipid-droplet · correlation 0.87
- Colonocyte terminal differentiation · correlation 0.83
- Long-gene nuclear transcripts · correlation 0.83
- JUN stress response · correlation 0.82
- Epithelial junction polarity · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.