Junctional Hippo/TGF-beta signaling
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
SMAD3 (TGF-beta), AFDN (adherens junction), DST (dystonin), WWC1 (KIBRA, Hippo), UACA and DAPK2. Together these suggest junctional/cytoskeletal adhesion signaling coupled with TGF-beta and Hippo pathways. The genes are long and broadly detected, so a partial long-gene bias is possible. The best biological label is junctional adhesion signaling.
Genes
AFDN, BACH1, CCNL1, DAPK2, DST, PELI2, SMAD3, UACA, WWC1
Most correlated modules
- TNF receptor signaling · correlation 0.88
- Stress-responsive transcription · correlation 0.87
- Brush-border enterocyte · correlation 0.87
- Epithelial junction polarity · correlation 0.87
- Long-gene nuclear transcripts · correlation 0.86
- Surface colonocyte lipid-droplet · correlation 0.82
- JUN stress response · correlation 0.81
- Apical junction complex · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.