Cytokine Chemokine Secretion
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
This module is dominated by canonical pro-inflammatory cytokines and chemokines: CXCL3, CXCL1, CXCL8 (IL-8) are neutrophil-recruiting CXC chemokines; IL-6 is a pleiotropic pro-inflammatory cytokine; CSF3 (G-CSF) promotes neutrophil production; CCL2 recruits monocytes; TNFAIP6 is an anti-inflammatory hyaluronan-binding protein induced by TNF/IL-1. RIPK2 is a kinase downstream of NOD1/2 innate immune receptors. G0S2 is a cell cycle/lipolysis regulator induced in inflammation. GLIS3 is a transcription factor. The module shows the strongest inflammation delta scores in the batch (UC: 0.456, CD: 0.611) and decreases with remission. This is a classic NF-κB-driven cytokine/chemokine secretory program in intestinal fibroblasts, consistent with inflammatory CAF (cancer-associated fibroblast-like) or activated stromal fibroblast states in IBD.
Genes
CCL2, CSF3, CXCL1, CXCL3, CXCL8, G0S2, GLIS3, IL6, RIPK2, TNFAIP6
Most correlated modules
- Inflammatory Fibroblast Activation · correlation 0.77
- Cytokine Inflammatory Response · correlation 0.76
- NF-κB Stress Response · correlation 0.73
- Hypoxia Metabolic Stress · correlation 0.70
- AP-1 Inflammatory Stress · correlation 0.69
- OSM Cytokine Response · correlation 0.66
- Interferon Response · correlation 0.65
- NF-κB Inflammatory Activation · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.