Cytokine Inflammatory Response
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes THBS1, SOCS1, CXCL2, MAP3K8, TNFAIP2, MMP19 define a TNF/cytokine-driven inflammatory activation program in fibroblasts. CXCL2 is a neutrophil-recruiting chemokine, MAP3K8 (COT1) is a key inflammatory kinase, SOCS1 is a JAK-STAT feedback inhibitor, TNFAIP2 is TNF-induced, and MMP19 reflects matrix remodeling. Significant upregulation in CD inflammation (delta_inflammation_CD=0.446) supports in vivo inflammatory relevance. THBS1 activates latent TGF-β and modulates immune responses. RND3 regulates cytoskeletal dynamics downstream of inflammatory signals. GFPT2 links to metabolic reprogramming in activated fibroblasts.
Genes
CXCL2, DNAJB4, GFPT2, HES4, MAP3K8, MMP19, RASL11A, RGCC, RND3, SOCS1, THBS1, TNFAIP2, VMP1
Most correlated modules
- NF-κB Stress Response · correlation 0.88
- Hypoxia Metabolic Stress · correlation 0.81
- NF-κB Immediate Early · correlation 0.80
- Integrated Stress Response · correlation 0.79
- Proteotoxic Stress Survival · correlation 0.79
- Cytokine Chemokine Secretion · correlation 0.76
- Fibroblast Quiescence · correlation 0.74
- Unfolded Protein Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.