G0S2 — G0/G1 switch 2
G0S2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
G0S2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Cytokine Chemokine Secretion Inflammatory | CCL2, CSF3, CXCL1, CXCL3, CXCL8, GLIS3, IL6, RIPK2 +1 more | View in SCUBA |
| Monocytes | NF-κB Signaling Inflammatory | BIRC3, ERN1, ICAM1, IER3, IRAK2, NFKB1, PDE4B, PNRC1 +4 more | View in SCUBA |
| Neutrophils | Inflammasome IL-1 Response Cytokine & chemokine secretion | CSRNP1, EGR3, IER3, IFRD1, IL1B, IL1RN, IVNS1ABP, LPCAT1 +5 more | |
| Pericytes | Basement Membrane Remodeling ECM remodeling | ADA, C4orf48, CYBA, DKK3, EFEMP2, ISG20, LAMB3, RCN3 +2 more | View in SCUBA |
About the gene
| Chromosome | 1: 209675412-209676390 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.