Metabolic Homeostasis
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include PGM1 (glycogen/glucose-1-phosphate metabolism), ALDH2 (mitochondrial aldehyde dehydrogenase), ADH5 (formaldehyde/alcohol dehydrogenase), ISCU (iron-sulfur cluster assembly critical for mitochondrial metabolism), TXNDC17 (thioredoxin-domain redox regulation), and RAB7A (late endosomal trafficking). Together these represent a metabolic homeostasis program involving carbohydrate metabolism, redox balance, and mitochondrial function. The module decreases significantly with inflammation and recovers in UC remission, consistent with suppression of homeostatic metabolic programs during active IBD. VGLL4 (Hippo pathway) and SMARCB1 (chromatin remodeling) add regulatory context. NBL1 is a BMP antagonist expressed in stromal cells.
Genes
ADH5, ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG, RAB7A, SMARCB1, TPBG, TXNDC17, VGLL4
Most correlated modules
- Actin Cytoskeletal Organization · correlation 0.92
- Myofibroblast Subtype · correlation 0.86
- Caveolae Mechanosensing · correlation 0.84
- Heparan Sulfate Remodeling · correlation 0.84
- Lysosomal Cytoskeletal · correlation 0.82
- Basement Membrane ECM · correlation 0.82
- TGF-beta Response · correlation 0.82
- IL-1 Receptor Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.