Unfolded Protein Response

Gene co-expression module in Fibroblasts

View this module in SCUBA

Why this annotation

ERN1 (IRE1α, the primary UPR sensor/endonuclease) is a key member; SLC38A2 is a well-established ATF4/UPR target induced during amino acid deprivation and ER stress; HNRNPU, HNRNPA2B1, SFPQ, DDX3X, HNRNPH1 are RNA-binding proteins recruited to stress granules and involved in integrated stress response mRNA regulation; EIF4A1 is a translation initiation factor regulated during ISR; STAT3 and ADM are downstream stress/inflammatory effectors; AFF4 and ZFAND5 participate in stress-linked transcription and proteasome stress. The module represents the RNA-level arm of the unfolded protein/integrated stress response. Neighbor context: flanked by heat shock (M86), immediate early (M102), and autophagy/ISR (M45) modules, all part of the same proteostasis stress neighborhood.

Genes

ADM, AFF4, DDX3X, DLL1, EIF4A1, ERN1, HNRNPA2B1, HNRNPH1, HNRNPU, RBBP6, SFPQ, SLC38A2, STAT3, ZFAND5

Most correlated modules

• Chromatin Transcriptional Regulation · correlation 0.90
• Heat Shock Response · correlation 0.90
• Integrated Stress Response · correlation 0.88
• Co-transcriptional RNA Processing · correlation 0.85
• Fibroblast Quiescence · correlation 0.79
• NF-κB Stress Response · correlation 0.78
• Proteotoxic Stress Survival · correlation 0.76
• Hypoxia-driven EMT · correlation 0.75

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.