Heat Shock Response

Gene co-expression module in Fibroblasts

View this module in SCUBA

Why this annotation

CHORDC1 (cysteine and histidine-rich domain-containing protein 1, HSP90 co-chaperone), HSPH1 (HSP105/HSP110, large heat shock protein), IER5 (immediate early response gene 5, induced by heat shock and activates PP2A to dephosphorylate HSF1 targets), GADD45B (stress/DNA damage response), and MIDN (midnolin, stress-responsive) anchor this as a heat shock response module. TRA2B, SRSF3, CCNL1, CLK1, and BCLAF1 represent the splicing regulatory arm activated during heat shock (CLK1 phosphorylates SR proteins; heat shock alters splicing). SLC2A3 (GLUT3) is upregulated under metabolic stress. NOLC1 links to nucleolar stress. The module captures the transcriptional and splicing reprogramming arm of the heat shock response.

Genes

BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5, MIDN, NOLC1, SEMA4A, SLC2A3, SRSF3, TRA2B

Most correlated modules

• Integrated Stress Response · correlation 0.91
• NF-κB Immediate Early · correlation 0.91
• Fibroblast Quiescence · correlation 0.90
• Unfolded Protein Response · correlation 0.90
• Proteotoxic Stress Survival · correlation 0.90
• NF-κB Epigenetic Reprogramming · correlation 0.86
• Type I Interferon · correlation 0.85
• Chromatin Transcriptional Regulation · correlation 0.85

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.