Proteotoxic Stress Survival
Gene co-expression module in Fibroblasts
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes BAG3 (chaperone-assisted autophagy, anti-apoptotic), PPIF (mitochondrial permeability transition pore cyclophilin D), DNAJA4 (heat shock co-chaperone), PPP1R15B (constitutive stress phosphatase), TNFRSF10D (TRAIL decoy receptor/apoptosis inhibitor), TIPARP (PARP stress response), ICAM1 (inflammatory adhesion), and SLC25A25 (mitochondrial Ca2+ buffering) collectively define a proteotoxic stress survival program combining chaperone activity, mitochondrial stress protection, and apoptosis resistance. Increased in CD inflammation and UC remission. Neighbor context: sits adjacent to other stress/UPR modules (M39, M86, M102, M45), consistent with a proteotoxic stress neighborhood.
Genes
ARL5B, BAG3, DNAJA4, ICAM1, PPIF, PPP1R15B, SLC25A25, TIPARP, TNFRSF10D
Most correlated modules
- Integrated Stress Response · correlation 0.92
- NF-κB Epigenetic Reprogramming · correlation 0.91
- Heat Shock Response · correlation 0.90
- NF-κB Immediate Early · correlation 0.89
- Type I Interferon · correlation 0.81
- Cytokine Inflammatory Response · correlation 0.79
- Fibroblast Quiescence · correlation 0.77
- Unfolded Protein Response · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.