RBBP6 — RB binding protein 6, ubiquitin ligase
RBBP6 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RBBP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Signaling Regulation BCR/AP1/NFKb pathway | CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP +5 more | View in SCUBA |
| CD4⁺ T cells | Glucocorticoid Immunoregulation Immune regulation | AHNAK, BTG1, CRIP1, GGNBP2, IDS, INSIG1, IRS2, JUND +11 more | View in SCUBA |
| Fibroblasts | Unfolded Protein Response Stress | ADM, AFF4, DDX3X, DLL1, EIF4A1, ERN1, HNRNPA2B1, HNRNPH1 +5 more | View in SCUBA |
| Gamma-delta T cells | Ubiquitin-p53 Regulation Protein processing & ER | ATXN7, CCNL1, DCTN4, FNBP1, HERPUD2, MOB4, RNF139, TP53BP2 +4 more | |
| Glial cells | Anti-proliferative mRNA Decay Stress | ABHD5, BCL6, EIF4A1, FUS, GADD45A, MAT2A, PLK2, TOB1 +4 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Decay Program RNA processing & translation | ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DUSP2, DYNLL2 +13 more |
About the gene
| Synonyms | P2P-R, PACT, SNAMA |
|---|---|
| Chromosome | 16: 24537693-24572863 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | DNA damage, DNA replication, Host-virus interaction, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication. (Microbial infection) Restricts ebolavirus replication probably by impairing the vp30-NP interaction, and thus viral transcription
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.