SLC38A2 — Solute carrier family 38 member 2
SLC38A2 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC38A2's module in each cell type
About the gene
| Synonyms | ATA2, KIAA1382, SAT2, SNAT2 |
|---|---|
| Chromosome | 12: 46358188-46372773 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Essential proteins, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Ion transport, Sodium transport, Symport, Transport |
Function
Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier. May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.