Hypoxia-driven EMT
Gene co-expression module in Fibroblasts
| Category | Stress |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes CITED2 (HIF-1α co-activator, hypoxia response), DDIT4/REDD1 (mTOR inhibitor induced by hypoxia and stress), SNAI1 (EMT master transcription factor), HBEGF (stress/growth factor induced by hypoxia and inflammation), and HEXIM1 (P-TEFb inhibitor regulating transcriptional pausing) define a hypoxia-driven stress response with EMT features. RASD1 is cAMP-regulated, MAFB is a stress-responsive TF, TOB1 is anti-proliferative, and PIK3R3 links to PI3K/AKT signaling. IER5L and ARC are immediate-early response genes consistent with the stress neighborhood (neighbor M52). In intestinal fibroblasts, this program likely reflects hypoxic microenvironmental stress driving partial EMT/myofibroblast activation.
Genes
ARC, CITED2, CSKMT, DDIT4, FAM43A, FAM53C, HBEGF, HEXIM1, IER5L, MAFB, PIK3R3, PLCG2, RASD1, SNAI1, TOB1, WDR74
Most correlated modules
- Chromatin Transcriptional Regulation · correlation 0.93
- Co-transcriptional RNA Processing · correlation 0.90
- Unfolded Protein Response · correlation 0.75
- Fibroblast Quiescence · correlation 0.73
- Heat Shock Response · correlation 0.68
- Type I Interferon · correlation 0.63
- NF-κB Immediate Early · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.