Integrated Stress Response
Gene co-expression module in Fibroblasts
| Category | Stress |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 18 genes have a known function matching the annotation |
Why this annotation
MAP1LC3B (LC3B, autophagosome marker) and SQSTM1 (p62, autophagy receptor) are the canonical autophagy markers. ATF4 is the master transcription factor of the integrated stress response (ISR) downstream of eIF2α phosphorylation. ZFAND2A (AIRAP) is a proteasome stress sensor induced by arsenite/proteotoxic stress. HSPD1 (HSP60) and HSPE1 (HSP10) are mitochondrial chaperones induced under mitochondrial/proteotoxic stress. DNAJB6 is a chaperone involved in protein aggregation prevention. HSP90AB1 is a major cytosolic chaperone. UBE2D3 is a ubiquitin-conjugating enzyme. PLK3 is a stress-activated kinase. MAFG and YBX3 are stress-responsive TFs. EIF4A3 and EIF5 link to translational stress. The module represents the integrated stress response with autophagy induction.
Genes
ATF4, BAIAP2, DNAJB6, EIF4A3, EIF5, FSCN1, HSP90AB1, HSPD1, HSPE1, ING1, MAFG, MAP1LC3B, PLK3, SQSTM1, UBE2D3, VASN, YBX3, ZFAND2A
Most correlated modules
- Proteotoxic Stress Survival · correlation 0.92
- Heat Shock Response · correlation 0.91
- NF-κB Epigenetic Reprogramming · correlation 0.89
- Unfolded Protein Response · correlation 0.88
- NF-κB Immediate Early · correlation 0.84
- Fibroblast Quiescence · correlation 0.82
- NF-κB Stress Response · correlation 0.81
- Cytokine Inflammatory Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.