Fibroblast Quiescence
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes KLF2 and KLF4 are canonical markers of fibroblast quiescence and homeostasis. BTG1 is anti-proliferative, ID2 inhibits differentiation, and RHOB regulates cytoskeletal homeostasis. UBB/UBC (ubiquitin) and UBE2S support protein quality control in a steady-state cell. SRSF5/SRSF7 are constitutive splicing factors. EIF4A2/EIF1 support baseline translation. High pct positive (56.7%) and mean expression (1.282) are consistent with a broadly expressed homeostatic program. The module is not inflammatory and lacks stress markers, supporting a quiescent fibroblast identity.
Genes
BTG1, EIF1, EIF4A2, FNIP1, ID2, KLF2, KLF4, RHOB, SRSF5, SRSF7, TUBB4B, UBB, UBC, UBE2S
Most correlated modules
- NF-κB Immediate Early · correlation 0.92
- Heat Shock Response · correlation 0.90
- Co-transcriptional RNA Processing · correlation 0.82
- Integrated Stress Response · correlation 0.82
- Type I Interferon · correlation 0.82
- Chromatin Transcriptional Regulation · correlation 0.81
- Unfolded Protein Response · correlation 0.79
- Proteotoxic Stress Survival · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.