Co-transcriptional RNA Processing
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes FUS (RNA binding/splicing), RSRP1 (serine/arginine-rich splicing-related), INTS6 (Integrator complex subunit regulating RNA Pol II pausing and snRNA processing), PCF11 (cleavage and polyadenylation factor), and PPP1R10 (chromatin-associated phosphatase regulator) define a co-transcriptional RNA processing program. TSPYL2 is involved in chromatin remodeling and transcriptional regulation. IFRD1 is a transcriptional co-repressor. YME1L1 is a mitochondrial protease but may be peripherally associated. The module reflects the machinery of transcriptional elongation, splicing, and 3' end processing — a housekeeping RNA biogenesis program.
Genes
FUS, IFRD1, INTS6, PCF11, PPP1R10, RSRP1, TSPYL2, YME1L1
Most correlated modules
- Chromatin Transcriptional Regulation · correlation 0.93
- Hypoxia-driven EMT · correlation 0.90
- Unfolded Protein Response · correlation 0.85
- Fibroblast Quiescence · correlation 0.82
- Heat Shock Response · correlation 0.82
- Type I Interferon · correlation 0.80
- NF-κB Immediate Early · correlation 0.66
- Integrated Stress Response · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.