SEC62 — SEC62 homolog, preprotein translocation factor
SEC62 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEC62's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B-cell identity B cell maturation | ALOX5AP, CD79B, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SIAH2 +7 more | View in SCUBA |
| CD4⁺ T cells | Ribosome biogenesis Housekeeping | APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA +17 more | View in SCUBA |
| Fibroblasts | Translation Initiation Housekeeping | CCNI, CD99, CNBP, EIF3E, EIF3F, ESD, HNRNPA1, ITM2B +3 more | View in SCUBA |
| Innate lymphoid cells | Innate Inflammatory Activation Inflammation | ARL6IP5, BST2, CD2, CD63, FTL, HMGB1, ITM2B, MGST3 +7 more | View in SCUBA |
| Lymphatic endothelial | Integrin Focal Adhesion migration & adhesion | APLP2, ATP5F1A, ATP5PB, DEK, ITGB1, LIMS1, MCFD2, NPC2 +4 more | View in SCUBA |
| Macrophages | ER Protein Translocation Vesicular traficking | ACADVL, ARRB2, BCL7B, BORCS7, DDRGK1, DEF8, DNAJB12, DVL3 +22 more | View in SCUBA |
| Pericytes | ER-Actin Cytoskeletal Cytoskeletal | A2M, CSDE1, GTF2I, IQGAP1, KTN1, MAP4K4, SERINC1, WASF2 | View in SCUBA |
About the gene
| Synonyms | Dtrp1, HTP1, TLOC1 |
|---|---|
| Chromosome | 3: 169966635-169998373 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Protein transport, Translocation, Transport |
Function
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.