ER Protein Processing
Gene co-expression module in Fibroblasts
| Category | Vesicular traficking |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
KDELR2 encodes the KDEL receptor that retrieves ER-resident proteins from the Golgi. LMAN1 (ERGIC-53) is a lectin cargo receptor cycling between ER and Golgi. RER1 mediates ER retrieval of membrane proteins. SSR3 is a subunit of the signal sequence receptor/translocon-associated protein complex. OSTC is part of the oligosaccharyltransferase complex for N-glycosylation. P4HB (PDI) and PRDX4 are ER oxidoreductases for oxidative protein folding. TMED3 is another p24 COPI cargo receptor. YIF1A is involved in ER-to-Golgi transport. PSMD7 and PSMC4 are proteasome subunits (ERAD). ARPC2 is Arp2/3 complex actin nucleation. ENO1 is glycolytic. The module has the highest inflammation delta in this batch (0.351 UC), consistent with heightened ER secretory/folding activity in inflamed fibroblasts. Closely related to M108 (shared TMED family, COPI, proteasome components).
Genes
ARPC2, ENO1, GTF3C6, KDELR2, LMAN1, OSTC, P4HB, PRDX4, PSMC4, PSMD7, RER1, SSR3, TMED3, YIF1A
Most correlated modules
- Proteasome Assembly · correlation 0.97
- ER-Golgi Trafficking · correlation 0.96
- Lysosomal Stress Response · correlation 0.96
- Proteasome Biogenesis · correlation 0.95
- ER Secretory Processing · correlation 0.93
- Cullin-RING Ubiquitin Ligase · correlation 0.93
- Rho GTPase Cytoskeletal · correlation 0.92
- Mitochondrial Energy Metabolism · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.