SCUBA

SNRPG — Small nuclear ribonucleoprotein polypeptide G

SNRPG belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SNRPG's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsSpliceosome snRNP
RNA processing
CHCHD2, COX7B, GHITM, MAGOH, PPIA, RAN, SNRPB, SNRPC +4 moreView in SCUBA
CD8⁺ T cellsCellular Housekeeping
Housekeeping
ACAT2, ACOT7, CISD2, FDPS, NUDT21, PA2G4, PPIA, PSMC3 +9 moreView in SCUBA
FibroblastsProteasome Biogenesis
Housekeeping
EIF5A, MRPL14, NME1, NOP10, POMP, SEC61B, SEC61G, SNRPD1 +1 moreView in SCUBA
Gamma-delta T cellsMitochondrial ETC
Mitochondrial & OxPhos
COX7B, HMGB1, HMGN1, HMGXB4, LSM5, NDUFB6, PSMA6, RANGRF +5 more
Glial cellsER Stress Response
Stress
ANXA1, ARF4, CSNK1A1, HSPA5, KRT10, RAB32, RBM3, SERP1 +4 moreView in SCUBA
Goblet cellsSpliceosome Assembly
RNA processing & translation
ALYREF, ANAPC11, BANF1, LSM4, MRPL51, PPIH, PTBP1, RAN +8 moreView in SCUBA
Innate lymphoid cellsMitochondrial Housekeeping
Mitochondrial & OxPhos
COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 moreView in SCUBA
Lymphatic endothelialProteasome Assembly
Protein processing & ER
ARPC2, CSTB, DEGS1, GSTO1, MRPL14, PDCD5, POMP, PRELID1 +5 moreView in SCUBA
MacrophagesSpliceosomal snRNP
Cell cycle
ANAPC11, BANF1, CCDC25, CCT8, ERH, FIBP, FKBP3, GLRX5 +30 moreView in SCUBA
Natural Killer cellsMetabolic Activation
Metabolism
FABP5, LDHA, NCL, NOP56, POMP, PTMA, SERBP1, SLC25A3 +2 moreView in SCUBA
Smooth muscle cellsRibonucleoprotein & translation
RNA processing & translation
CRYAB, CYB5R3, EEF1B2, HMGB1, HNRNPC, LAPTM4A, MAGED2, NACA +5 moreView in SCUBA

About the gene

SynonymsSm-G
Chromosome2: 70281362-70293740
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Function

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.