SCUBA

MRPL14 — Mitochondrial ribosomal protein L14

MRPL14 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MRPL14's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChaperonin Protein Folding
Protein processing & ER
BANF1, CCT2, CCT3, CCT4, CCT5, CCT6A, EIF2S1, ILF2 +5 moreView in SCUBA
CD4⁺ T cellsNF-kB activation
TCR/AP1/NFKb pathway
ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 moreView in SCUBA
EndothelialOxidative Phosphorylation
Mitochondrial & OxPhos
ATP5F1D, ATP5MC2, ATP5PO, COX7C, ERP29, HIGD2A, HINT1, IMPDH2 +10 moreView in SCUBA
FibroblastsProteasome Biogenesis
Housekeeping
EIF5A, NME1, NOP10, POMP, SEC61B, SEC61G, SNRPD1, SNRPE +1 moreView in SCUBA
Innate lymphoid cellsMitochondrial Lysosomal Housekeeping
Mitochondrial & OxPhos
BTF3L4, C14orf119, EMC6, ETFA, IER3IP1, JTB, LAMP1, MRPS16 +7 moreView in SCUBA
Lymphatic endothelialProteasome Assembly
Protein processing & ER
ARPC2, CSTB, DEGS1, GSTO1, PDCD5, POMP, PRELID1, PSMD7 +5 moreView in SCUBA
MacrophagesProtein Homeostasis Mixed
Housekeeping
ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Ribosome
Mitochondrial & OxPhos
AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DCTPP1, DYNC1I2 +22 more

About the gene

SynonymsMRP-L32, RPML32
Chromosome6: 44113451-44127452
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins, Ribosomal proteins
Molecular functionRibonucleoprotein, Ribosomal protein

Function

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.