POMP — Proteasome maturation protein

POMP belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

POMP's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	OxPhos & redox Mitochondrial & OxPhos	ATOX1, CHCHD2, HNRNPR, KIF5B, MRPS21, NDUFAB1, NDUFB1, NDUFB2 +5 more	View in SCUBA
CD8⁺ T cells	Mitochondrial OxPhos Mitochondrial & OxPhos	COX6B1, COX6C, COX7A2, COX7B, DBI, ELOB, LSM7, NDUFB2 +5 more	View in SCUBA
Endothelial	Vascular Tone Regulation Endothelial cell development	ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81 +13 more	View in SCUBA
Fibroblasts	Proteasome Biogenesis Housekeeping	EIF5A, MRPL14, NME1, NOP10, SEC61B, SEC61G, SNRPD1, SNRPE +1 more	View in SCUBA
Gamma-delta T cells	snRNP Splicing RNA processing & translation	CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more
Glial cells	Proteostasis Stress Response Stress	ATOX1, ATP5MG, ATP6V0E1, C19orf53, C4orf3, COX7B, CYSTM1, GUK1 +7 more	View in SCUBA
Goblet cells	ER Protein Processing Protein processing & ER	ALG5, ARPC1A, ARPC3, COPZ1, DAD1, DYNLT1, PSMA5, SPCS1	View in SCUBA
Innate lymphoid cells	Mitochondrial Housekeeping Mitochondrial & OxPhos	COX7A2, COX7B, EEF1B2, EIF1AX, FTH1, HNRNPC, ID2, NAP1L1 +8 more	View in SCUBA
Lymphatic endothelial	Proteasome Assembly Protein processing & ER	ARPC2, CSTB, DEGS1, GSTO1, MRPL14, PDCD5, PRELID1, PSMD7 +5 more	View in SCUBA
Macrophages	ATP Synthase Complex Mitochondrial & OxPhos	ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6 +14 more	View in SCUBA
Monocytes	TNF-driven Activation Inflammatory	ATP13A3, CD44, DCUN1D3, DSE, GK, IVNS1ABP, LAMB3, LITAF +3 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Splicing m6A RNA processing & translation	ARF1, ARF6, ATP5F1B, CIRBP, CORO7, EIF1B, EIF5A, EMD +15 more
Natural Killer cells	Metabolic Activation Metabolism	FABP5, LDHA, NCL, NOP56, PTMA, SERBP1, SLC25A3, SNRPG +2 more	View in SCUBA
Smooth muscle cells	Basal Metabolic Housekeeping Housekeeping	ARPC2, C11orf58, C1orf43, C4orf3, CNBP, COX17, GUK1, HNRNPDL +6 more	View in SCUBA

About the gene

Synonyms	C13orf12, HSPC014, UMP1
Chromosome	13: 28659065-28678959
Predicted location	Intracellular
Essential gene	Yes
Protein class	Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins
Molecular function	Chaperone

Function

Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.