NFIX — Nuclear factor I X
NFIX belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFIX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Homeostasis Endothelial cell development | APOL3, BMX, EXOC6, FAXDC2, FTH1, GABARAPL1, GAS6, GIMAP1 +10 more | View in SCUBA |
| Fibroblasts | Microfibril ECM Fibroblast ECM production | CD302, CD81, COX7C, CYBRD1, EPHX1, MFAP4, NOP53, NUCKS1 +2 more | View in SCUBA |
| Glial cells | Glial Neural Scaffolding Cytoskeletal | AKAP6, ARHGAP24, COL5A3, EIF4G2, PPP1R12B, SCAF11, SEMA6D, USP53 | View in SCUBA |
| Smooth muscle cells | Integrin adhesion complex Migration & adhesion | ALDH1B1, ALDH2, DST, FERMT2, ITGA5, KLHL42, METTL7A, NPTN +3 more | View in SCUBA |
About the gene
| Synonyms | NF1A |
|---|---|
| Chromosome | 19: 12995475-13098796 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | DNA replication, Transcription, Transcription regulation |
Function
Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.