PROS1 — Protein S
PROS1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PROS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ACVRL1, ANXA11, ATP13A2, ENG, HPCAL1, HYAL1, LDB2, MACF1 +7 more | View in SCUBA |
| Fibroblasts | Microfibril ECM Fibroblast ECM production | CD302, CD81, COX7C, CYBRD1, EPHX1, MFAP4, NFIX, NOP53 +2 more | View in SCUBA |
| Lymphatic endothelial | Innate Immune Activation Immune regulation | CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3 +9 more | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PCSK1N +6 more | View in SCUBA |
About the gene
| Synonyms | PROS |
|---|---|
| Chromosome | 3: 93873051-93980003 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Blood coagulation, Fibrinolysis, Hemostasis |
Function
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.