SNX3 — Sorting nexin 3
SNX3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNX3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Membrane Transport Endothelial cell development | AQP1, CDH24, CEBPG, CLIC5, FAP, LSM6, OIT3, OSTF1 +9 more | View in SCUBA |
| Fibroblasts | General Housekeeping Housekeeping | ATP6V0E1, C19orf53, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A +4 more | View in SCUBA |
| Gamma-delta T cells | Proteostasis/Chaperonin Protein processing & ER | BST2, CARD16, CBR1, CCT3, CCT6A, DOK2, DYNLL1, HIKESHI +13 more | |
| Innate lymphoid cells | Protein Biogenesis & Import Protein processing & ER | ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5 +6 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Neutrophils | Pentose Phosphate Pathway Housekeeping | ANXA3, ARPC2, CAP1, CDA, GYG1, HMGB2, LBR, PGD +1 more | |
| Smooth muscle cells | Respiratory Chain Subunits Mitochondrial & OxPhos | C19orf53, COX6A1, COX7B, MZT2B, NDUFB1, PFN1, SNRPD2, UBXN1 +2 more | View in SCUBA |
About the gene
| Synonyms | Grd19 |
|---|---|
| Chromosome | 6: 108211222-108261246 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Protein transport, Transport |
Function
Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.