Lysosomal Biogenesis
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
Top hub gene GNPTAB encodes GlcNAc-1-phosphotransferase alpha/beta subunits, the enzyme responsible for mannose-6-phosphate tagging of lysosomal hydrolases — a defining step in lysosomal biogenesis and enzyme targeting. CD63 is a canonical lysosome-associated tetraspanin. APLP2 traffics through the secretory/endolysosomal pathway. FBXO6 targets glycoproteins for ERAD. ABI3 and DOCK5 contribute actin/migration-related functions. MYO6 mediates endosomal/lysosomal vesicle transport. The lysosomal biogenesis and vesicular trafficking program anchored by GNPTAB and CD63 is the dominant signal, with ABI3/DOCK5 adding a migration component consistent with neighboring module M139.
Genes
ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, DOCK5, EML2, FBXO6, FNDC3B, GNPTAB, KIFC3, MAGED2, MYO6, NMUR1, PLAAT3, PLEKHF1, PPM1L, SDF2, SMIM29, TENT5A, TMCC3
Most correlated modules
- Actin-based Motility · correlation 0.77
- Proteostasis/Chaperonin · correlation 0.59
- Tissue-resident gd T · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.