SCUBA

SELENOW — Selenoprotein W

SELENOW belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SELENOW's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsCytoskeleton/motility
migration & adhesion
ANXA2, ANXA4, BHLHE41, C4orf48, CAPG, CAPN2, CIB1, ISCU +11 moreView in SCUBA
EnterocytesSurface colonocyte transport
Absorption
CA4, CD46, CITED1, CLCN1, DOCK4, GSN, HSPB1, ITM2C +4 moreView in SCUBA
FibroblastsECM Homeostasis
ECM remodeling
CAST, CAVIN3, FAM114A1, HCFC1R1, MXRA7, PPIC, TIMP2, TUBBView in SCUBA
Gamma-delta T cellsProteostasis/Chaperonin
Protein processing & ER
BST2, CARD16, CBR1, CCT3, CCT6A, DOK2, DYNLL1, HIKESHI +13 more
Glial cellsAntioxidant Stress Response
Stress
AP2S1, CSTB, DYNLRB1, HSBP1, MAGED2, NDUFB11, PLPP1, PPDPF +1 moreView in SCUBA
Innate lymphoid cellsTranscription RNA Processing
RNA processing & translation
ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 moreView in SCUBA
Lymphatic endothelialCaveolae Cytoskeletal
Cytoskeletal
CALM1, CAVIN1, CRIP2, CTSZ, DYNLL1, EPHX1, GSTK1, HOXD8 +7 moreView in SCUBA
MacrophagesOxidative Metabolic Program
Mitochondrial & OxPhos
ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 moreView in SCUBA
Mucosal-associated invariant T cellLeukocyte Housekeeping
Housekeeping
AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG +5 more
PericytesImmunoproteasome Induction
Inflammatory
CANX, GRN, LY6E, NUCB1, PGK1, PSAP, PSMB8, PSMB9 +3 moreView in SCUBA
Smooth muscle cellsATP Synthase Complex
Mitochondrial & OxPhos
ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1E, ATP5MC1, ATP5MC2, ATP5MC3, ATP5ME +8 moreView in SCUBA

About the gene

SynonymsSELW, SEPW1
Chromosome19: 47778677-47784686
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionAntioxidant

Function

Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.