TWF1 — Twinfilin actin binding protein 1
TWF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TWF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Decay Regulation RNA processing & translation | BAG5, BAP1, BRAP, CEP120, HAUS3, IKZF5, MVD, NARF +9 more | |
| Macrophages | ER Protein Quality Control Lysosomal & pahgocytosis | ACP2, C5orf15, CLN5, CS, CTBP1, ERGIC3, FUT11, GANAB +18 more | View in SCUBA |
About the gene
| Synonyms | A6, PTK9 |
|---|---|
| Chromosome | 12: 43793723-43806328 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Molecular function | Actin-binding |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.