Wnt-STAT3 Signaling
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
CTNNB1 (beta-catenin) is the central effector of Wnt signaling. STAT3 is a JAK-STAT pathway transcription factor with roles in T cell survival and differentiation. NUP153 and TNPO1 are nuclear transport machinery components critical for signaling factor import. PAFAH1B1 (LIS1) regulates dynein and microtubule dynamics. DHX9 is an RNA helicase. ZC3HAV1 (ZAP) is an antiviral/innate sensor. YWHAZ (14-3-3zeta) scaffolds multiple signaling pathways. EZR (ezrin) links membrane receptors to cytoskeleton. COPA is involved in ER-Golgi trafficking. The module is anchored by two major oncogenic/survival signaling hubs (CTNNB1, STAT3) with supporting nuclear transport and cytoskeletal components.
Genes
BTBD1, COPA, CTNNB1, DHX9, EZR, HECTD1, NUP153, PAFAH1B1, SPRTN, STAT3, TNPO1, TOPORS, YWHAZ, ZC3HAV1
Most correlated modules
- Transcription-RNA Coupling · correlation 0.89
- Spliceosome Regulation · correlation 0.86
- Hypoxia Stress Response · correlation 0.86
- Pre-mRNA Splicing · correlation 0.86
- Hippo Pathway Signaling · correlation 0.84
- mRNA Decay Regulation · correlation 0.83
- Transcriptional Coactivation · correlation 0.82
- Chromatin Epigenetic Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.