Glycolysis & Proteasome
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSME2 (proteasome activator REG-beta), PKM (pyruvate kinase M), LDHB (lactate dehydrogenase B), ENO1 (enolase 1), PFKL (phosphofructokinase liver isoform), PSMB2/PSMD4 (proteasome subunits), UBE2L6 (ubiquitin-conjugating enzyme E2L6, ISG15-conjugating), APEH (acylpeptide hydrolase/proteasome-associated), PARP1 (DNA repair). The module clearly co-activates glycolytic enzymes (PKM, LDHB, ENO1, PFKL) together with the ubiquitin-proteasome system (PSME2, PSMB2, PSMD4, UBE2L6). LCK (T cell signaling) and C1QBP (mitochondrial/ribosome biogenesis) are peripheral. This combination of glycolysis + proteasome activation is characteristic of metabolically active, proliferating or activated T cells.
Genes
ACAA2, ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1, HINT1, LCK, LDHB, PARP1, PFKL, PKM, PSMB2, PSMD4, PSME2, RPA1, UBE2L6, WDR46
Most correlated modules
- Complex I Assembly · correlation 0.88
- General Housekeeping Mixed · correlation 0.88
- Actin Remodeling · correlation 0.87
- Basal Cell Maintenance · correlation 0.85
- Cytotoxic Effector Actin · correlation 0.84
- Transcriptional Elongation Control · correlation 0.83
- Chaperone Protein Folding · correlation 0.82
- Protein Homeostasis Chaperones · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.