Mitochondrial Housekeeping
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include MRPS21 (mitochondrial ribosome small subunit), SSBP1 (mitochondrial single-stranded DNA binding), SURF1 (cytochrome c oxidase assembly), HAX1 (mitochondrial anti-apoptotic), with supporting VPS28/CHMP4A (ESCRT vesicle pathway) and LSM6 (RNA splicing). The dominant theme is mitochondrial function (ribosome, DNA maintenance, assembly factors) with peripheral RNA processing and membrane trafficking genes. Uniform expression across subsets is consistent with housekeeping mitochondrial programs. Neighbor context (batch-wide housekeeping/metabolic modules) supports this classification.
Genes
ARL2, BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3, HAX1, IAH1, IFI35, LSM6, METTL5, MRPS21, PIN4, PPP1R35, SSBP1, SURF1, THYN1, UBL4A, VPS28, VPS72
Most correlated modules
- Mitochondrial Translation · correlation 0.90
- Mitochondrial Dynamics · correlation 0.88
- General Housekeeping Mixed · correlation 0.87
- Mitoribosome Small Subunit · correlation 0.86
- Complex I Assembly · correlation 0.86
- Oxidative Phosphorylation · correlation 0.86
- Chaperone Protein Folding · correlation 0.86
- Basal Cell Maintenance · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.